Elde Lab

department of human genetics








Rheinemann L., Downhour D.M., Davenport K.A., McKeown A.N., Sundquist W.I., Elde N.C. Recurrent Emergence of an Antiviral Defense through Repeated Retrotransposition and Truncation of CHMP3. bioRxiv. https://doi.org/10.1101/2021.04.27.441704


Goldstein S.A., Brown J., Pedersen B.S., Quinlan A.R., Elde N.C. Extensive recombination-driven coronavirus diversification expands the pool of potential pandemic pathogens. bioRxiv. https://doi.org/10.1101/2021.02.03.429646


Fixsen S.M., Cone K.R., Goldstein S.A., Sasani T.A., Quinlan A.R., Rothenburg S., Elde N.C. Poxviruses capture host genes by LINE-1 retrotransposition. bioRxiv. https://doi.org/10.1101/2020.10.26.356402


Rheinemann L., Downhour D.M., Bredbenner K., Mercenne G., Davenport K.A., Schmitt P.T., Necessary C.R., McCullough J., Schmitt A.P., Simon S.M., Sundquist W.I., Elde N.C. (2021) RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis. Cell, 184: 5419-5431.e16.


Carey C.M., Apple S.E., Hilbert Z.A., Kay M.S., Elde N.C. (2021) Diarrheal pathogens trigger rapid evolution of the Guanylate Cyclase-C signaling axis in bats. Cell Host and Microbe, 29: 1342-1350.e5


Sorouri M., Chang T., Jesudhasan P., Pinkham C., Elde N.C., Hancks D.C. Signatures of host–pathogen evolutionary conflict reveal MISTR—A conserved MItochondrial STress Response network. (2020). Plos Biology, 18: e3001045.


Balla K.M., Rice M.C., Gagnon J.A., Elde N.C. (2020) Linking Virus Discovery to Immune Responses Visualized during Zebrafish Infections. Current Biology, 30: 2092-2103.e5


Boguslawski K.M., McKeown A.N., Day C.J., Lacey K.A., Tam K., Vozhilla N., Kim S.Y., Jennings M.P., Koralov S.B., Elde N.C., Torres V.J.(2020) Exploiting species specificity to understand the tropism of a human-specific toxin. Science Advances, 6: eaax7515.


Rubenstein D.R., Agren J.A., Carbone L., Elde N.C., Hoekstra H.E., Kapheim K.M., Keller L., Moreau C.S., Toth A.L., Yeaman S., Hofmann H.A. (2019) Coevolution of Genome Architecture and Social Behavior. Trends in Ecology and Evolution, 34: 844-855.


Carey C.M., Govande A.A., Cooper J.M., Hartley M.K., Kranzusch P.J., Elde N.C. (2019) Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates. Cell Host and Microbe, 25: 336-343.e4.


Sasani T.A., Cone K.R., Quinlan A.R., Elde N.C. (2018) Long read sequencing reveals poxvirus evolution through rapid homogenization of gene arrays. eLife, 7: e35453.


Barber M.F., Lee E.M., Griffin H., Elde N.C. (2017) Rapid evolution of primate type 2 immune response factors linked to asthma susceptibility. Genome Biology and Evolution, 9: 1757-1765.


Cone K.R., Kronenberg Z.N., Yandell M., Elde N.C. (2017) Emergence of a viral RNA polymerase variant during gene copy number amplification promotes rapid evolution of vaccinia virus. Journal of Virology, 91: e01428-16.


Chuong E.B., Elde N.C., Feschotte C. (2017) Regulatory evolution of transposable elements: from conflicts to benefits. Nature Reviews Genetics, 18: 71-86.


Yaxin Y., Yarrington R.M., Choung E.B., Elde N.C., Stillman D.J. (2016) Disruption of promoter memory by a long noncoding RNA. Proc Natl Acad Sci U S A., 113: 9575-80.


Barber M.F., Kronenberg Z., Yandell M., Elde N.C. (2016) Antimicrobial functions of lactoferrin promote genetic conflicts in ancient primates and modern humans. PLOS Genetics, 12: e1006063.


Chuong E.B., Elde N.C.,* Feschotte, C.* (2016) Regulatory evolution of innate immunity through co-option of endogenous retroviruses. Science, 351: 1083-7.

*equal contributions


Kronenberg Z.N., Osborne E.J., Cone K.R., Kennedy B.J., Domyan E.T., Shapiro M.D., Elde N.C., Yandell M. (2015) Wham: Identifying structural variants of biological consequence. PLOS Computational Biology, 11: e1004572.


Barber M.F., Elde N.C. (2015) Buried treasure: Evolutionary perspectives on microbial iron piracy. Trends in Genetics, 31: 627-36.


Li J., Cao C., Fixsen S.M., Young J.M., Ono C., Bando H., Elde N.C., Katsuma S., Dever T.E., Sicheri F. (2015) Baculovirus protein PK2 subverts eIF2alpha kinase function by mimicry of its kinase domain C-lobe. Proc Natl Acad Sci U S A., 112: e4364-73.


Hancks D.C., Hartley M.K., Hagan C., Clark N.L., Elde N.C. (2015) Overlapping patterns of rapid evolution in the nucleic acid sensors cGAS and OAS suggest a common mechanism of pathogen antagonism and escape. PLOS Genetics, 11: e1005203.


Orzalli M.H., Broekema N.M., Diner B.A., Hancks D.C., Elde N.C., Cristea I.M., Knipe D.M. (2015) cGAS and IFI16 cooperate by a novel mechanism to sense nuclear herpesviral DNA. Proc Natl Acad Sci U S A., 112: 1773-81.


DePaula-Silva A.B., Cassiday P.A., Chumley J., Bosque A., Monteiro-Filho C.M., Mohan C.S., Cone K.R., Krogan N., Elde N.C., Planelles V. (2015) Determinants for degradation of SAMHD1, Mus81 and induction of G2 arrest in HIV-1 Vpr and SIVagm Vpr. Virology, 477: 10-17.


Galati D.F., Bonney S., Kronenberg Z., Clarissa C., Yandell M., Elde N.C., Jerka-Dziadosz M., Giddings T.H., Frankel J., Pearson C.G. (2014) DisAp-dependent striated fiber elongation is required to organize ciliary arrays. Journal of Cell Biology, 207: 705-15.


Barber M.F., Elde N.C. (2014) Escape from bacterial iron piracy through rapid evolution of transferrin. Science, 346: 1362-6.     ABSTRACT      FULL-TEXT        REPRINT


Barber M.F., Elde N.C. (2013) Mimicry all the way down. Nature, 501: 38-9.


Elde N.C. (2012) Poliovirus evolution: the strong, silent type. Cell Host & Microbe, 12: 605-6.


Elde N.C., Child S.J., Eickbush M.T., Kitzman J.O., Rogers, K.S., Shendure J., Geballe A.P., Malik H.S. (2012) Poxviruses deploy genomic accordions to adapt rapidly against host antiviral defenses. Cell, 150: 831-841.


Sawyer, S.L., Elde N.C. (2012) A cross-species view on viruses. Current Opinion in Virology, 2: 561-8.


Elde N.C., Roach, K., Yao M.C., Malik H.S. (2011) Absence of positive selection on centromeric histones in Tetrahymena suggests unsuppressed centromere-drive in lineages lacking male meiosis. Journal of Molecular Evolution, 72: 510-520.


Elde N.C., Malik H.S. (2009) The evolutionary conundrum of pathogen mimicry. Nature Reviews Microbiology, 7: 787-797.


Elde N.C., Child S.J., Geballe A.P., Malik H.S. (2009) Protein kinase R reveals an evolutionary model for defeating viral mimicry. Nature, 457: 485-489.


Rahaman A., Elde N.C., Turkewitz A.P. (2008) A dynamin-related protein required for nuclear remodeling in Tetrahymena. Current Biology, 18: 1227-1233.


Elde N.C., Long M., Turkewitz A.P. (2007) A role for convergent evolution in the secretory life of cells.  Trends in Cell Biology, 17: 157-164.


Eisen J.A., Wu M., Wu D., Thiagarajan M., Wortman J.R., Badger J.H., Ren Q., Delcher A.L., Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M., Carlton J.M., Garg J., Pearlman R.E., Karrer K.M., Sun L., Smith R.K., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y., Cai H., Collins K., Wilamowska K., Ruzzo W.L., Weinberg Z., Stewart B.W., Lee S.R., Wloga D., Rogowski K., Frankel J., Gaertig J., Gorovsky M.A., Cherry J.M., Stover N.A., Krieger C.J., Hamilton E.P., Orias E., Coyne R.S. (2006) Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biology, 4: e286.


Elde N.C., Morgan G., Winey M., Sperling L., Turkewitz A.P. (2005) Elucidation of clathrin-mediated endocytosis in Tetrahymena reveals an evolutionarily convergent recruitment of dynamin. PLoS Genetics, 1: e52.


Bowman G.R., Elde N.C., Morgan G., Winey M., Turkewitz A.P. (2005) Core formation and the acquisition of fusion competence are linked during secretory granule maturation in Tetrahymena. Traffic, 6: 303-323.


Doherty K.R., Zweifel E.W., Elde N.C., McKone M.J., Zweifel S.G. (2003) Random amplified polymorphic DNA markers reveal genetic variation in the symbiotic fungus of leaf-cutting ants. Mycologia, 95: 19-23.


Chilcoat N.D., Elde N.C., Turkewitz A.P. (2001) An antisense approach to phenotype-based gene cloning in Tetrahymena. Proc Natl Acad Sci U S A, 98: 8709-13.


evolutionary genetics & cell biology