Elde Lab

department of human genetics

UNIVERSITY

OF UTAH

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pathogen-driven evolution

arms races

mimicry

experimental evolution

evolutionary genetics & cell biology

While experiments based on phylogenetic reconstructions, provide a powerful means of retrospectively studying host-pathogen interactions, experimental evolution offers a prospective view of virus evolution where potential adaptations can be monitored in real-time. Recent advances in deep sequencing coupled with recombinant tools make it possible to quickly determine the genetic basis of a variety of adaptations.  We are using experimental evolution to address open questions related to virus evolution, such as mechanisms of rapid evolution and the trade-offs between host range and virulence.

Schematic of a protocol for experimental evolution